The Wang lab systematically examines how epigenetic mechanisms and chromosomal architecture drive cellular phenotypes and behaviors.
We have developed an interdisciplinary training environment in an effort to harness emerging techniques to answer fundamental questions of biological and clinical significance in gene regulation, inflammation, and regenerative medicine. Research in the Wang Lab is directed towards deciphering the regulatory circuitry that controls cell state and differentiation in mammalian systems. We use a variety of experimental and computational technologies to determine how long noncoding RNAs, three-dimensional chromatin architecture, chromatin dynamics, and novel growth factors control gene expression programs in pluripotent stem cells and specific immune populations. Along the way, we create and implement new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ innovative methodologies and apply them across multiple cellular and organismal systems to garner a mechanistic understanding of the rules that govern and dictate cellular behaviors.